Regan Hofmann is the editor-in-chief of POZ magazine, a publication and a website for people living with and affected by HIV/AIDS. She herself has lived with HIV since 1996, and she first publicly disclosed her HIV positive status in April 2006, appearing on POZ's cover above the words “I am no longer afraid to say I have HIV.”

Hofmann is also a board member of the Foundation for AIDS Research (amfAR) as well as many other AIDS activism groups. She has served as a U.S. delegate at the United Nations’ General Assembly’s Special Session on AIDS and has traveled internationally on behalf of the U.S. Department of State to speak about HIV/AIDS and stigma. 

In 2009, Simon and Schuster recently published Hofmann’s memoir I Have Something to Tell You.