“The big discovery has been that depressed patients who have proven most resistant to traditional treatments seem to have particularly high rates of inflammation.” “Inhibiting inflammatory cytokines … seems to help alleviate depressive symptoms.” “If this association holds, keeping inflammatory cytokines in check could also help treat conditions beyond classic depression, such as cancer-related fatigue or even chronic fatigue syndrome, Miller noted. And because much of the inflammation in question seems to be coming from outside of the brain…new depression-targeting drugs might not even have to cross the blood-brain barrier to have palliative effects.”