Altered States

Altered States

A blue hand holding a tool touches a red illustrated brain, with brain wave patterns shown in the background.
A new framework suggests that bursts of neural chaos could be the fingerprints of a conscious mind at work.
A split image showing the left half of a frog and the right half of a chemical structure on a green and white textured background.
5-MeO-DMT may offer a practical way to access and study consciousness in its most basic form.
Painting of a man with red hair and a mustache wearing a white cap, resting his head on his hand, set against a swirling blue background with touches of van Gogh yellow paint highlighting the scene.
In "Human History on Drugs," Sam Kelly explores what the research can tell us about one of history’s most brilliant — and troubled — artists.
Abstract image featuring a luminous, symmetrical pattern of blue and white swirling lines against a dark background, resembling a cosmic or nebula-like formation.
A look inside Mindstate Design Labs' effort to design drugs that reliably produce specific states of mind.
An orange fruit hangs from a branch, accompanied by a small white flower with pink details, set against a background of green leaves.
A powerful psychedelic long used in African rituals shows surprising promise for treating traumatic brain injury and PTSD.
Abstract image with intertwined black and white wispy lines forming a chaotic, web-like pattern on a dark background.
Delirium is one of the most perplexing deathbed phenomena, exposing the gap between our cultural ideals of dying words and the reality of a disoriented mind.
Person sleeping with EEG cap and sensors on face, covered with a purple blanket.
"The amount of interest is enormous," says anesthesiologist Boris Heifets. "People are dropping in and coming out of the woodwork, trying to understand how to do this."
Illustration of human evolution with silhouettes of ape to human walking against an abstract background with swirling red and white patterns.
The controversial theory about magic mushrooms and human evolution gets a much-needed update.
A person is sleeping, dreaming of a woman packing multiple bags and suitcases.
"Upon emergence, these patients are sincerely unsure what was reality and what was a ‘dream.'"
A person with long hair faces the ocean, wearing a white shirt. A sheer gray fabric is draped over their face, obscuring their eyes. The background is cloudy with a view of the sea.
Propofol, a drug commonly used for general anesthesia, derails the brain’s normal balance between stability and excitability.
Illustration of a young woman with closed eyes, smiling, next to a large, detailed eye and surrounded by vibrant, abstract elements and smiley faces.
A recent study suggests that exposure to visual stimuli can diminish the effects of psychedelic drugs.
An abstract digital collage inspired by alien abduction stories, with a monochrome vinyl record at the center surrounded by colorful, glitch-like textures and shapes.
The truth may be out there — but it’s not in these close encounters of the third kind.
An illustration of a hand with mechanical fingers and wires, symbolizing the inception of dreams in the integration of technology with the human body.
One MIT-trained poet spent nine months trying to find out.
A black and white photo of a person's brain.
Here's the thorny reality behind psychedelics' ability to unearth buried memories.
A person cutting a diamond with a pair of tweezers while under the influence of LSD.
Benjamin Breen on his greatest revelations while writing about the birth of psychedelic science.
A collage of images capturing a woman with her eyes closed, hinting at the possibility of sleep deprivation.
Big Think recently spoke with sleep psychologist Dr. Jade Wu about the surprising consequences of forgoing sleep.
A man in a suit hypnotizing a woman.
Many still consider hypnosis more of a cheap magician’s trick than legitimate clinical medicine.
Charles bridge in prague, czech republic.
Uncovering the story of Milan Hausner, the Sadská clinic, and LSD psychotherapy behind the Iron Curtain.
An image of a human heart in flames.
The heart's rhythms may play a larger role in shaping psychedelic experiences than previously thought.
A silhouette of a person experiencing a near-death encounter in front of a fire.
Millions of people have had a near-death experience, and it often leads them to believe in an afterlife. Does this count as good proof?
Monks in red robes walking in the snow during biostasis.
Inside the “out there” quest for a drug that would help doctors save lives before it’s too late.
A man is having a near-death experience while laying in a hospital bed.
Only about 10% of patients survive cardiac arrest. Of the ones who do, many have amazing stories to tell.
A map of a city with a lot of pink dots.
Legally smoking joints in city centers will require alertness and a keen sense of orientation — two things stoners are not known for.
A woman is looking at herself in a mirror.
In a psychedelic state, the relationship between your “narrative” and “minimal” selves seems to transform in unique ways.
A cloud over Mount Shasta with a mountain in the background.
The mountain can generate lenticular clouds, which may contribute to its supernatural reputation.