Pain Pathways

Pain Pathways

Book cover of "Tell Me Where It Hurts" by Rachel Zoffness, PhD, featuring a pain scale from green to red under the title and subtitle about the science and 3 pillars of pain and healing.
By better understanding how the brain constructs pain, we may transform how we treat chronic suffering.
A man slumps in a chair, eyes closed, as small monkey-like creatures torment him with various objects in a room near a fireplace and table.
In "The Headache," Tom Zeller Jr. explores one of the human brain's most enduring, and painful, enigmas.
X-ray images of a shoulder and a wrist with highlighted areas in red indicating injuries or inflammation, set against a colorful, abstract background.
Fixing chronic pain in the body may sometimes require a treatment focused on the brain.
A man with glasses giving a thumbs up.
6mins
You know Steve-O. Now meet Steve Glover, as the professional stuntman talks to us about pain, insecurity, and never finding contentment.
Unlikely Collaborators
A man consuming capsaicin-rich chili peppers in a vibrant red field.
Capsaicin is already used to treat nerve pain. Early research hints it could do more.
A man sitting at a table with a cup of tea, experiencing chronic pain.
Chronic pain is often driven by brain processes that can be reprogrammed.
A healthy endocannabinoid system is critical to the human body’s immune functions.
When migraine and tension-headache patients overuse their medications, they can actually trigger more headaches.
Researchers are looking at neurons required for touch-mediated pain relief.
The placebo effect is real. So are the ethical conundrums posed by those who would exploit the latest research advances for profit.
The cannabis plant produces both THC – the psychoactive component in marijuana – and the compound commonly known as CBD, which does not lead to a "high."
cancer radiation
There may be a faster, less-painful way to use radiation against cancer.
Music and sounds only seem to reduce pain in mice when played at a specific volume.
From ibuprofen to fentanyl, it’s about meeting the pain where it’s at.
neuropathic pain
Scientists found a way to revert pain in mice using gene therapy. Perhaps the same technique could be applied to humans.
chronic pain
Drugs that stifle acute inflammation may prevent the body from healing properly.
swearing
Profanity offers surprising benefits. But why?
Plants are very sensitive to touch, with research showing that touching a plant can change its genome and launch a cascade of plant hormones.
“At that time, it was just a wild idea, [...] that instead of just a loss of consciousness, anesthetics may do something to the brain that actually turns pain off.”
therapy dog
A ten-minute visit from a therapy dog reduces emergency room patients' pain and anxiety.
painkillers
Painkillers have nasty side effects, such as organ damage or addiction. Researchers have discovered a new drug that may cause none of these.